Dr. Anna Klimovich | G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far-Eastern Branch of the Russian Academy of Sciences | Russia
Dr. Anna Klimovich is a PhD candidate in biochemistry with a decade of experience as a research fellow, specializing in the investigation of biologically active compounds derived from marine organisms of the Far Eastern and tropical seas using advanced experimental models of human pathologies in laboratory animals. She works as a research assistant in the Laboratory of Molecular Pharmacology and Biomedicine at the Pacific Institute of Bioorganic Chemistry, contributing extensively to fundamental and applied biomedicine. Her scientific portfolio includes 40 publications indexed in Web of Science and Scopus, supported by 199 citations across 162 documents and an h-index of 8, reflecting her strong research impact. She has completed seven research projects and is an inventor or co-inventor on seven patents focused on bioactive marine compounds and their therapeutic potential. Her research areas span biology, biochemistry, biomedicine, natural biologically active substances, and preclinical trials, with collaborative work involving Far Eastern Federal University in Vladivostok. Dr. Klimovich has contributed significantly to the characterization of marine peptides and metabolites, including the sea anemone peptide HCRG21, which exhibits analgesic, anti-inflammatory, and anxiolytic activities and demonstrates therapeutic potential for allergic dermatitis and psoriasis. She has also studied the peptide HCIQ2c1 with anti-inflammatory and neuroprotective properties, and the sea anemone peptides Hcr 1b-2, Hcr 1b-4, and AnmTX Sco 9a-1, which show strong anxiolytic, anti-inflammatory, and analgesic effects. Her work further includes discovering the antidiabetic and antiglycemic activities of the peptide Mgf, evaluating antimicrobial and antitumor effects of phenylphascaplysine alkaloid derivatives, and identifying the ability of triterpene glycosides from sea cucumbers—Cucumarioside A0-1, Djakonovioside A—and the peptide Hct-S3 to inhibit tumor metastasis. Additionally, she contributed to demonstrating that asterripeptides A–C from marine fungi possess therapeutic activity in treating infected wounds. Her research advances marine-derived therapeutic discoveries with high relevance to pharmacology, biotechnology, and translational biomedicine.
Featured Publications
Klimovich, A., Kvetkina, A., Deryavko, Y., Priymenko, N., Popkova, D., Bystritskaya, E., Isaeva, M., Gladkikh, I., Sintsova, O., & Leychenko, E. (2025). TRPV1 blocker, peptide HCRG21 from sea anemone Heteractis magnifica, exhibits effectiveness in psoriasis and dermatitis in in vivo models. International Journal of Molecular Sciences, 26(21), 10644. https://doi.org/10.3390/ijms262110644
Klimovich, A. A., Chingizova, E. A., Pislyagin, E. A., Kotelnikov, V. N., & Shperling, I. A. (2025). Eksperimental’no-funktsional’naya otsenka ranozazhivlyayushchey aktivnosti gidrogelya na osnove karboksimetiltsellyulozy s biologicheski aktivnymi veshchestvami iz gidrobiontov Tikhogo okeana pri termicheskom ozhoge [Experimental and functional evaluation of the wound-healing activity of a carboxymethylcellulose-based hydrogel with bioactive substances from Pacific Ocean hydrobionts in a thermal burn model]. Clinical and Fundamental Medicine, 2, 5–12. https://doi.org/10.24866/3033-5485/2025-2/5-12
Zhidkov, M. E., Smirnova, P. A., Grammatikova, N. E., Isakova, E. B., Shchekotikhin, A. E., Styshova, O. N., Klimovich, A. A., & Popov, A. M. (2025). Comparative evaluation of the antibacterial and antitumor activities of marine alkaloid 3,10-dibromofascaplysin. Marine Drugs, 23(2), 68. https://doi.org/10.3390/md23020068
Klimovich, A. A., Kvetkina, A. N., Deryavko, Y. V., Priymenko, N. A., & Leychenko, E. V. (2024). Peptide TRPV1 channel blocker, HCRG21, effectively suppresses inflammation in a calcipotriol-induced allergic dermatitis model. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18, (Issue no. pending). https://doi.org/10.1134/S1990750824601127
Pavlenko, A. P., Klimovich, A. A., Yurchenko, E. A., Kvetkina, A. N., & Leychenko, E. V. (2024). Sea anemone Heteractis magnifica toxin Hct-S3 suppresses the migration of solid Ehrlich adenocarcinoma cells inoculated into BALB/C mice. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18, (Issue no. pending). https://doi.org/10.1134/S1990750824601206
Klimovich, A. A., Styshova, O. N., Popov, A. M., Moskvina, T. V., Tsybulsky, A. V., Derunov, D. A., & Stonik, V. A. (2020). Experimental study of therapeutic efficacy of the topical preparation “Kourochitin” in skin allergy. Letters in Drug Design & Discovery, 17(10), 1234–1241.