Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award

Published on by Invention Awards

Dr. Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award 

University of Malaga | Spain

Dr. Dasiel Oscar Borroto Escuela is an internationally recognized neuroscientist whose research has fundamentally advanced the understanding of G protein–coupled receptor (GPCR) heteroreceptor complexes and their role in brain function and disease. His work focuses on elucidating how alterations in GPCR heteroreceptor complexes and their allosteric receptor–receptor interactions contribute to the pathogenesis of neuropsychiatric and neurodegenerative disorders, including major depression, addiction, and Parkinson’s disease. Dr. Borroto Escuela is a pioneer in the discovery and characterization of GPCR–GPCR and GPCR–RTK interactions in the central nervous system, providing compelling molecular evidence that these complexes constitute critical integrative signaling units underlying learning, memory, and brain plasticity. His seminal publications in Biological Psychiatry, Molecular Psychiatry, Neuropsychopharmacology, and Trends in Pharmacological Sciences have reshaped prevailing neurotransmitter hypotheses by introducing receptor heterocomplex dynamics as key determinants of disease vulnerability and therapeutic response. A major contribution of his work is the proposal that changes in the density and allosteric interactions of GPCR heterocomplexes represent a shared molecular mechanism linking psychiatric and neurodegenerative disorders. He has notably extended the serotonin hypothesis of depression by integrating molecular dynamics within serotonin receptor heterocomplexes, identifying new targets for antidepressant intervention. Dr. Borroto Escuela has also developed and refined cutting-edge methodologies, including the establishment and optimization of in situ proximity ligation assay (PLA) techniques, enabling the in-brain visualization of GPCR heteroreceptor complexes—a methodological breakthrough that has become foundational in the field. His characterization of heteromer interface interactions, such as the D2R–A2AR heterodimer, has opened new avenues for drug development using small interfering peptides. Currently, as an EMERGIA Fellow at the University of Málaga, Dr. Borroto Escuela leads the Receptomics & Brain Disease Lab, while simultaneously directing the GPCR Laboratory at Karolinska Institutet. He has secured competitive funding from prestigious Spanish and Swedish agencies and foundations and has produced over 180 peer-reviewed publications, with more than 5,000 citations and an h-index exceeding 40. Beyond research, he is deeply committed to scientific leadership, serving as editor and editorial board member for leading journals, evaluator for international funding agencies, supervisor of over 60 students, and an invited speaker at more than 40 international conferences. His career reflects sustained excellence, innovation, and global impact in neuroscience and neuropsychopharmacology.

Citation Metrics (Scopus)

6000
5000
4000
3000
2000
1000
  500
  400
  300
  200
  100
    50
    10
      0

Citations
6000

Documents
201

h-index
47

Citations

Documents

h-index

View Scopus Profile
     View Orcid Profile

Featured Publications

Yuniesky Andrade-Talavera | Neuroscience | Best Innovation Award

Published on by Invention Awards

🌟Dr. Yuniesky Andrade-Talavera, Neuroscience, Best Innovation Award🏆

Doctorate at Universidad Pablo de Olavide, Spain

Yuniesky Andrade Talavera is a Marie Skłodowska-Curie Postdoctoral Fellow at the Universidad Pablo de Olavide (UPO), Spain. His research expertise lies in neurophysiology, neuronal network dynamics, neuropharmacology, neurodegenerative disorders, and synaptic plasticity.

Author Metrics

Scopus Profile

ORCID Profile

Yuniesky Andrade Talavera has published 32 peer-reviewed articles, 23 of which appear in Q1 journals according to the Journal Citation Reports (JCR). He has an h-index of 17 and an i10-index of 21, with his work receiving a total of 842 citations on Google Scholar and 677 on Scopus.

Education

Andrade Talavera completed his Ph.D. at the Universidad Pablo de Olavide, Spain, in 2012, earning Cum Laude honors. He also holds a Master’s degree from both the Universidad Pablo de Olavide and the National Centre for Scientific Research in Cuba, obtained in 2009. His academic journey began with a Bachelor’s degree in Biology from the University of Havana, Cuba, in 2004.

Research Focus

His research focuses on understanding the mechanisms of synaptic plasticity, the dynamics of neuronal networks, and the pathology of neurodegenerative disorders like Alzheimer’s disease. He investigates the roles of neurons and glial cells in brain rhythmicity and synaptic behavior, aiming to uncover therapeutic strategies for cognitive impairments.

Professional Journey

Andrade Talavera has held various research positions, starting as a Ph.D. student at UPO, followed by postdoctoral roles at UPO and the Karolinska Institutet in Sweden. His work at these institutions involved significant contributions to understanding long-term synaptic depression and neuronal network oscillations in neurodegenerative conditions.

Honors & Awards

He has received multiple honors, including the Extraordinary Ph.D. Award from UPO in 2013, a Postdoctoral College Grant from the Wenner-Gren Foundation in 2019, and the Seal of Excellence from the European Commission in 2022. Additionally, he was awarded a Marie Curie Postdoctoral Fellowship and a research grant from the Regional Andalusia Government’s Excellence Program.

Publications Noted & Contributions

Significant publications include articles in Trends in Neuroscience and Molecular Psychiatry, highlighting his work on synaptic plasticity and neuronal oscillations. Notable contributions include discovering mechanisms of long-term synaptic depression and identifying therapeutic targets for Alzheimer’s disease.

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer’s disease

Journal: Progress in Neurobiology
Publication Date: April 2024
DOI: 10.1016/j.pneurobio.2024.102585
ISSN: 0301-0082
Contributors: Riccardo Maccioni, Caterina Travisan, Jack Badman, Stefania Zerial, Annika Wagener, Yuniesky Andrade-Talavera, Federico Picciau, Caterina Grassi, Gefei Chen, Laetitia Lemoine, et al.
Summary: This study investigates the role of Signal peptide peptidase-like 2b (SPPL2b) in Alzheimer’s disease (AD). The research demonstrates that SPPL2b modulates the amyloidogenic pathway and its expression is dependent on amyloid-beta (Aβ) presence. The findings suggest that targeting SPPL2b could provide new therapeutic avenues for managing AD.

Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Journal: Translational Neurodegeneration
Publication Date: 2023
DOI: 10.1186/S40035-023-00338-0
WOSUID: WOS:000924688700001
Contributors: Luis Enrique Arroyo-Garcia, Sara Bachiller, Rocio Ruiz, Antonio Boza-Serrano, Antonio Rodriguez-Moreno, Tomas Deierborg, Yuniesky Andrade-Talavera, André Fisahn
Summary: This research explores the potential of targeting galectin-3 to mitigate the disruption of spike-phase coupling in fast-spiking interneurons, which is crucial for gamma oscillations in the brain. The study’s outcomes indicate that galectin-3 modulation could restore gamma oscillations and ameliorate cognitive deficits in Alzheimer’s disease.

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Journal: Molecular Psychiatry
Publication Date: June 2023
DOI: 10.1038/s41380-023-02027-w
Contributors: Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno
Summary: This comprehensive review addresses the intricate mechanisms of spike timing-dependent plasticity (STDP), brain rhythmicity, and the role of glial cells in neuronal circuits. It highlights the significance of precise timing in neuronal communication and plasticity, with implications for understanding and treating neurological disorders.

Neuronal and astrocyte determinants of critical periods of plasticity

Journal: Trends in Neurosciences
Publication Date: May 2023
DOI: 10.1016/j.tins.2023.04.005
ISSN: 0166-2236
Contributors: Yuniesky Andrade-Talavera, Mikel Pérez-Rodríguez, José Prius-Mengual, Antonio Rodriguez-Moreno
Summary: This article examines the roles of neurons and astrocytes in determining the critical periods of synaptic plasticity. The authors discuss how these cell types influence plasticity windows, which are essential for cognitive development and neuroplasticity, providing insights into potential therapeutic strategies for neurodevelopmental and neurodegenerative diseases.

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease mice

Publication Date: April 12, 2023
DOI: 10.1101/2023.04.12.536603
Contributors: Maria Dolores Capilla-López, Angel Deprada, Yuniesky Andrade-Talavera, Irene Martínez-Gallego, Heriberto Coatl-Cuaya, José Rodríguez-Alvarez, Antonio Rodríguez-Moreno, Arnaldo Parra-Damas, Carlos A. Saura
Summary: This preprint presents research on the differential vulnerability of neural circuits to β-amyloid and tau pathologies using a novel Alzheimer’s disease mouse model. The study provides detailed insights into how specific neural circuits are affected differently by these pathological proteins, contributing to the understanding of disease progression and potential targets for intervention.

Research Timeline

From 2006 to 2022, Andrade Talavera progressed from a researcher candidate in Cuba to a Marie Curie Postdoctoral Fellow in Spain. Key periods include his postdoctoral research at the Karolinska Institutet (2016-2020) and his ongoing fellowship at UPO since 2023.

Collaborations and Projects

He has collaborated on 21 research projects, leading eight as principal investigator. His projects have secured funding from various Swedish bodies and the Regional Andalusia Government. Collaborative efforts have resulted in significant findings related to neuronal network dynamics and Alzheimer’s disease, often in partnership with international researchers.

Research Projects

Yuniesky Andrade Talavera has led several projects focused on Alzheimer’s disease, investigating therapeutic interventions and the role of neuronal networks. Key projects include funding from the Foundation for Geriatrics Diseases and the Swedish Research Council, emphasizing translational research to counteract amyloid-beta-induced cognitive deficits.