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🌟Dr. Yuniesky Andrade-Talavera, Neuroscience, Best Innovation Award🏆

Doctorate at Universidad Pablo de Olavide, Spain

Yuniesky Andrade Talavera is a Marie Skłodowska-Curie Postdoctoral Fellow at the Universidad Pablo de Olavide (UPO), Spain. His research expertise lies in neurophysiology, neuronal network dynamics, neuropharmacology, neurodegenerative disorders, and synaptic plasticity.

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Yuniesky Andrade Talavera has published 32 peer-reviewed articles, 23 of which appear in Q1 journals according to the Journal Citation Reports (JCR). He has an h-index of 17 and an i10-index of 21, with his work receiving a total of 842 citations on Google Scholar and 677 on Scopus.

Education

Andrade Talavera completed his Ph.D. at the Universidad Pablo de Olavide, Spain, in 2012, earning Cum Laude honors. He also holds a Master’s degree from both the Universidad Pablo de Olavide and the National Centre for Scientific Research in Cuba, obtained in 2009. His academic journey began with a Bachelor’s degree in Biology from the University of Havana, Cuba, in 2004.

Research Focus

His research focuses on understanding the mechanisms of synaptic plasticity, the dynamics of neuronal networks, and the pathology of neurodegenerative disorders like Alzheimer’s disease. He investigates the roles of neurons and glial cells in brain rhythmicity and synaptic behavior, aiming to uncover therapeutic strategies for cognitive impairments.

Professional Journey

Andrade Talavera has held various research positions, starting as a Ph.D. student at UPO, followed by postdoctoral roles at UPO and the Karolinska Institutet in Sweden. His work at these institutions involved significant contributions to understanding long-term synaptic depression and neuronal network oscillations in neurodegenerative conditions.

Honors & Awards

He has received multiple honors, including the Extraordinary Ph.D. Award from UPO in 2013, a Postdoctoral College Grant from the Wenner-Gren Foundation in 2019, and the Seal of Excellence from the European Commission in 2022. Additionally, he was awarded a Marie Curie Postdoctoral Fellowship and a research grant from the Regional Andalusia Government’s Excellence Program.

Publications Noted & Contributions

Significant publications include articles in Trends in Neuroscience and Molecular Psychiatry, highlighting his work on synaptic plasticity and neuronal oscillations. Notable contributions include discovering mechanisms of long-term synaptic depression and identifying therapeutic targets for Alzheimer’s disease.

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer’s disease

Journal: Progress in Neurobiology
Publication Date: April 2024
DOI: 10.1016/j.pneurobio.2024.102585
ISSN: 0301-0082
Contributors: Riccardo Maccioni, Caterina Travisan, Jack Badman, Stefania Zerial, Annika Wagener, Yuniesky Andrade-Talavera, Federico Picciau, Caterina Grassi, Gefei Chen, Laetitia Lemoine, et al.
Summary: This study investigates the role of Signal peptide peptidase-like 2b (SPPL2b) in Alzheimer’s disease (AD). The research demonstrates that SPPL2b modulates the amyloidogenic pathway and its expression is dependent on amyloid-beta (Aβ) presence. The findings suggest that targeting SPPL2b could provide new therapeutic avenues for managing AD.

Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Journal: Translational Neurodegeneration
Publication Date: 2023
DOI: 10.1186/S40035-023-00338-0
WOSUID: WOS:000924688700001
Contributors: Luis Enrique Arroyo-Garcia, Sara Bachiller, Rocio Ruiz, Antonio Boza-Serrano, Antonio Rodriguez-Moreno, Tomas Deierborg, Yuniesky Andrade-Talavera, André Fisahn
Summary: This research explores the potential of targeting galectin-3 to mitigate the disruption of spike-phase coupling in fast-spiking interneurons, which is crucial for gamma oscillations in the brain. The study’s outcomes indicate that galectin-3 modulation could restore gamma oscillations and ameliorate cognitive deficits in Alzheimer’s disease.

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Journal: Molecular Psychiatry
Publication Date: June 2023
DOI: 10.1038/s41380-023-02027-w
Contributors: Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno
Summary: This comprehensive review addresses the intricate mechanisms of spike timing-dependent plasticity (STDP), brain rhythmicity, and the role of glial cells in neuronal circuits. It highlights the significance of precise timing in neuronal communication and plasticity, with implications for understanding and treating neurological disorders.

Neuronal and astrocyte determinants of critical periods of plasticity

Journal: Trends in Neurosciences
Publication Date: May 2023
DOI: 10.1016/j.tins.2023.04.005
ISSN: 0166-2236
Contributors: Yuniesky Andrade-Talavera, Mikel Pérez-Rodríguez, José Prius-Mengual, Antonio Rodriguez-Moreno
Summary: This article examines the roles of neurons and astrocytes in determining the critical periods of synaptic plasticity. The authors discuss how these cell types influence plasticity windows, which are essential for cognitive development and neuroplasticity, providing insights into potential therapeutic strategies for neurodevelopmental and neurodegenerative diseases.

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease mice

Publication Date: April 12, 2023
DOI: 10.1101/2023.04.12.536603
Contributors: Maria Dolores Capilla-López, Angel Deprada, Yuniesky Andrade-Talavera, Irene Martínez-Gallego, Heriberto Coatl-Cuaya, José Rodríguez-Alvarez, Antonio Rodríguez-Moreno, Arnaldo Parra-Damas, Carlos A. Saura
Summary: This preprint presents research on the differential vulnerability of neural circuits to β-amyloid and tau pathologies using a novel Alzheimer’s disease mouse model. The study provides detailed insights into how specific neural circuits are affected differently by these pathological proteins, contributing to the understanding of disease progression and potential targets for intervention.

Research Timeline

From 2006 to 2022, Andrade Talavera progressed from a researcher candidate in Cuba to a Marie Curie Postdoctoral Fellow in Spain. Key periods include his postdoctoral research at the Karolinska Institutet (2016-2020) and his ongoing fellowship at UPO since 2023.

Collaborations and Projects

He has collaborated on 21 research projects, leading eight as principal investigator. His projects have secured funding from various Swedish bodies and the Regional Andalusia Government. Collaborative efforts have resulted in significant findings related to neuronal network dynamics and Alzheimer’s disease, often in partnership with international researchers.

Research Projects

Yuniesky Andrade Talavera has led several projects focused on Alzheimer’s disease, investigating therapeutic interventions and the role of neuronal networks. Key projects include funding from the Foundation for Geriatrics Diseases and the Swedish Research Council, emphasizing translational research to counteract amyloid-beta-induced cognitive deficits.

Yuniesky Andrade-Talavera | Neuroscience | Best Innovation Award

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