Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award

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Dr. Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award 

University of Malaga | Spain

Dr. Dasiel Oscar Borroto Escuela is an internationally recognized neuroscientist whose research has fundamentally advanced the understanding of G protein–coupled receptor (GPCR) heteroreceptor complexes and their role in brain function and disease. His work focuses on elucidating how alterations in GPCR heteroreceptor complexes and their allosteric receptor–receptor interactions contribute to the pathogenesis of neuropsychiatric and neurodegenerative disorders, including major depression, addiction, and Parkinson’s disease. Dr. Borroto Escuela is a pioneer in the discovery and characterization of GPCR–GPCR and GPCR–RTK interactions in the central nervous system, providing compelling molecular evidence that these complexes constitute critical integrative signaling units underlying learning, memory, and brain plasticity. His seminal publications in Biological Psychiatry, Molecular Psychiatry, Neuropsychopharmacology, and Trends in Pharmacological Sciences have reshaped prevailing neurotransmitter hypotheses by introducing receptor heterocomplex dynamics as key determinants of disease vulnerability and therapeutic response. A major contribution of his work is the proposal that changes in the density and allosteric interactions of GPCR heterocomplexes represent a shared molecular mechanism linking psychiatric and neurodegenerative disorders. He has notably extended the serotonin hypothesis of depression by integrating molecular dynamics within serotonin receptor heterocomplexes, identifying new targets for antidepressant intervention. Dr. Borroto Escuela has also developed and refined cutting-edge methodologies, including the establishment and optimization of in situ proximity ligation assay (PLA) techniques, enabling the in-brain visualization of GPCR heteroreceptor complexes—a methodological breakthrough that has become foundational in the field. His characterization of heteromer interface interactions, such as the D2R–A2AR heterodimer, has opened new avenues for drug development using small interfering peptides. Currently, as an EMERGIA Fellow at the University of Málaga, Dr. Borroto Escuela leads the Receptomics & Brain Disease Lab, while simultaneously directing the GPCR Laboratory at Karolinska Institutet. He has secured competitive funding from prestigious Spanish and Swedish agencies and foundations and has produced over 180 peer-reviewed publications, with more than 5,000 citations and an h-index exceeding 40. Beyond research, he is deeply committed to scientific leadership, serving as editor and editorial board member for leading journals, evaluator for international funding agencies, supervisor of over 60 students, and an invited speaker at more than 40 international conferences. His career reflects sustained excellence, innovation, and global impact in neuroscience and neuropsychopharmacology.

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Featured Publications

Rakib Miah | Neuroscience | Best Researcher Award

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Mr. Rakib Miah | Neuroscience | Best Researcher Award

Mr. Rakib Miah | University of Colorado Anschutz Medical Campus | United States

Mr. Rakib Miah is a dedicated biomedical researcher with expertise in biochemistry, molecular biology, and neuroscience, currently working at the University of Colorado Anschutz Medical Campus. His career has been defined by a commitment to understanding the molecular mechanisms of human diseases, with a strong focus on extracellular vesicles, ion-channel physiology, neuropathic pain, and molecular imaging. He has gained international recognition through his scientific contributions, publications, and research involvement in both laboratory and clinical studies. His academic and professional journey spans Bangladesh and the United States, reflecting a global perspective and scientific adaptability. Md. Rakib’s collaborative research efforts have advanced knowledge in cancer biology, cardiovascular health, metabolic disorders, and neuroscience. He combines strong technical expertise with leadership experience, mentoring undergraduate students and actively participating in scientific communities. His research aims to contribute toward the development of therapeutic solutions that address pressing global health challenges.

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Education

Mr. Rakib Miah pursued his academic career with distinction in biochemistry and molecular biology, building a strong foundation in biomedical sciences. He obtained his Bachelor of Science in Biochemistry and Molecular Biology from Shahjalal University of Science and Technology (SUST), Bangladesh, where he studied metabolic disorders and public health issues. He continued at SUST for his first master’s degree in Biochemistry and Molecular Biology, completing a thesis on the relationship between serum xanthine oxidase and hypertension. He later pursued his second master’s degree in Chemistry and Biochemistry at the University of Denver, United States, where his research focused on tetherin gene regulation, exosome secretion, and cancer biology under the mentorship of Professor Michelle Knowles. His advanced academic training provided him with hands-on experience in molecular biology, protein expression, immunofluorescence, and imaging. His education represents a balance of clinical insight and experimental expertise, preparing him to contribute to biomedical research innovation globally.

Professional Experience

Mr. Rakib Miah has demonstrated excellence across multiple scientific environments, from academic research to pharmaceutical quality control. At the University of Colorado Anschutz Medical Campus, he is working in the Department of Anesthesiology, where he performs cutting-edge experiments on animal models, patch-clamp electrophysiology, and preclinical drug trials targeting neuropathic pain. At the University of Denver, he contributed as a Graduate Research Assistant, conducting advanced work in mammalian cell culture, exosome isolation, protein purification, and fluorescence microscopy. Previously, at Beximco Pharmaceuticals Ltd., a leading US-FDA-approved pharmaceutical company, he served as a Quality Control Officer, gaining experience in analytical chemistry, HPLC, UV-Vis spectrophotometry, and certification processes. His early research internship at the National Institute of Biotechnology in Bangladesh introduced him to advanced molecular techniques, shaping his career in biomedical sciences. His professional trajectory illustrates an exceptional combination of laboratory precision, clinical research involvement, and interdisciplinary collaboration aimed at impactful scientific outcomes.

Research Interests

Mr. Rakib Miah’s research interests lie at the intersection of molecular biology, neurobiology, and translational medicine. His work focuses on unraveling cellular and molecular pathways in human diseases, with particular emphasis on exosomes and extracellular vesicles, which serve as biomarkers and mediators of intercellular communication. He is deeply interested in cancer biology, especially how tetherin protein regulation impacts exocytosis and cellular signaling in lung cancer cells. Additionally, his current projects explore ion-channel physiology, patch-clamp electrophysiology, and nociceptive activity in preclinical models, aiming to develop therapeutic approaches for neuropathic pain. His research extends into metabolic disorders, including hypertension, diabetes, and chronic kidney disease, providing valuable insights into population health. With expertise in microscopy, image analysis, and protein biochemistry, he combines advanced imaging with molecular techniques to link fundamental biology to clinical applications. His long-term goal is to translate laboratory discoveries into therapies for neurodegenerative, metabolic, and cancer-related conditions.

Awards & Recognitions

Mr. Rakib Miah has received multiple scholarships, fellowships, and recognitions for his academic excellence and research contributions. He was awarded the prestigious Graduate Dean’s Fellowship at the University of Denver to support his studies and research in molecular biology and exosome regulation. In Bangladesh, he was honored with the National Science and Technology Fellowship as a promising young researcher, recognizing his outstanding potential in biomedical sciences. His earlier achievements include merit-based scholarships from Dutch-Bangla Bank Foundation and Eastern Bank for his consistent academic performance during higher education. He has also won competitive awards at the school and college level, establishing his early commitment to academic excellence. His recognition extends to scientific events, where he presented research posters at international conferences organized by the National Young Academy of Bangladesh. These awards reflect his strong academic foundation, consistent research excellence, and his ability to inspire confidence as a young scientist with global potential.

Publication Top Notes

Pulsed radiofrequency of lumbar dorsal root ganglion versus epidural neuroplasty for lumbar radicular pain: a systematic review and network meta-analysis

Journal: Regional Anesthesia & Pain Medicine
Authors: Ji-Hoon Park, Jae Ni Jang, Soyoon Park, Young-Soon Choi, Dae Kyun Ryu, Rakib Miah, Sukhee Park


Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

Journal: BMC Endocrine Disorders
Authors: Zitu Barman, Mahmudul Hasan, Rakib Miah, Ananya Dutta Mou, Jaasia Momtahena Hafsa, Aporajita Das Trisha, Firoz Mahmud, Nurshad Ali


The association between elevated lipid profile and liver enzymes: a study on Bangladeshi adults

Journal: Scientific Reports
Authors: Rakib Miah, Rahanuma Raihanu Kathak, Abu Hasan Sumon, Noyan Hossain Molla, Mahmudul Hasan, Humaira Rashid Tuba, Ahsan Habib, Nurshad Ali


Association of serum xanthine oxidase levels with hypertension: a study on Bangladeshi adults

Journal: Scientific Reports
Authors: Rakib Miah, Khandaker Atkia Fariha, Sabrina Amita Sony, Shamim Ahmed, Mahmudul Hasan, Ananya Dutta Mou, Zitu Barman, Akibul Hasan, Nayan Chandra Mohanto, Nurshad Ali


Assessment of the relationship between serum xanthine oxidase levels and type 2 diabetes: a cross-sectional study

Journal: Scientific Reports
Authors: Mahmudul Hasan, Khandaker Atkia Fariha, Zitu Barman, Ananya Dutta Mou, Rakib Miah, Ahsan Habib, Humaira Rashid Tuba, Nurshad Ali

Conclusion

Mr. Rakib Miah is a highly promising biomedical researcher whose academic achievements, professional experiences, and scientific contributions demonstrate a consistent trajectory toward impactful research. His multidisciplinary expertise—from molecular biology and protein expression to neuroscience and metabolic health—reflects his ability to address complex scientific questions across diverse domains. His awards and scholarships highlight his recognition as a capable and innovative researcher with global relevance. The breadth of his publications across high-impact journals establishes him as an emerging scholar contributing to translational medicine and public health. His active involvement in mentorship, scientific societies, and humanitarian initiatives further showcases his leadership potential and social responsibility. With his strong commitment to discovery and problem-solving, Mr. Rakib Miah embodies the qualities of a researcher who is not only advancing science but also inspiring future directions in molecular medicine, neuroscience, and public health. He is an exceptional candidate for research recognition and awards.

Prof. Sergey Kozlov | Neuroscience | Best Researcher Award

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Prof. Sergey Kozlov | Neuroscience | Best Researcher Award

Shemiakin-Ovchinnikov Institute of bioorganic chemistry RAS, Russia.

Dr. Sergey Kozlov is a DSc and Head of the Laboratory of Neuroreceptors and Neuroregulators at the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry. He also teaches at the Federal State Russian Biotechnological University. His research focuses on the rational search for active molecules and the analysis of their structure-function relationships, particularly for potential healthcare applications. His most notable contributions include discovering ligands for acid-sensitive ion channels, which have promising therapeutic potential for treating pain, inflammation, drug addiction, anxiety, and neurodegenerative conditions such as stroke.

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🎓 Education

Prof. Sergey Kozlov is a distinguished scientist and educator specializing in bioorganic chemistry and biotechnology. He earned his Doctor of Science (DSc) from the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, where he conducted advanced research in biochemical processes and molecular interactions. Currently, he serves as a teaching faculty member at the Federal State Russian Biotechnological University, where he contributes to academic development and scientific research in biotechnology. With extensive expertise in biomolecular studies, Prof. Kozlov plays a crucial role in training future researchers and advancing innovation in bioorganic chemistry.

💼 Experience

Professor Sergey Kozlov is the Head of the Laboratory of Neuroreceptors and Neuroregulators at the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry. He is also a Professor & Researcher at the Federal State Russian Biotechnological University. Additionally, he collaborates with various Russian chemical laboratories on the functional testing of low molecular weight compounds.

His expertise likely involves bioorganic chemistry, neurobiology, and possibly pharmacology, with a focus on receptor interactions and the regulation of neurochemical processes in the brain.

🔬 Research Interests

Dr. Kozlov's research focuses on protein chemistry, including:

Separation of natural mixtures and structure determination

Activity analysis of compounds using imaging and electrophysiology

Development of animal models for testing new molecules

Production of recombinant proteins and receptor mutagenesis
His work has contributed significantly to understanding acid-sensitive ion channels, which play a role in pain management, inflammation, addiction, anxiety, and neurodegeneration.

🏆 Awards & Recognitions

Member – The International Society on Toxinology

Member – Federation of European Biochemical Societies (FEBS)

Hirsch Index: 28 (WoS)

Patents: 19 published, 2 under review

Consultancy/Industry Projects: 2 completed

Research Projects: 6 (4 completed, 2 ongoing)

📚 Selected Publications

Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity
Marine Drugs, Aug 2024 | DOI: 10.3390/md22090382
🧬 Examines peptide inhibitors of ASIC3 channels and their effect on pain relief.

Opioid Analgesic as a Positive Allosteric Modulator of Acid-Sensing Ion Channels
Int. J. Mol. Sci., Jan 2024 | DOI: 10.3390/ijms25031413
💊 Investigates opioid analgesics as modulators of ASIC channels for potential pain management.

Venom-gland transcriptomics and proteomics of the Tibellus oblongus spider
Dataset, Oct 2023 | DOI: 10.6084/m9.figshare.21842034
🕷️ Provides genomic insights into spider venom composition.

Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Int. J. Mol. Sci., Sep 2023 | DOI: 10.3390/ijms241813884
🏛️ Reviews five decades of toxin research at IBCh RAS.

Dual Modulator of ASIC Channels and GABA<sub>A</sub> Receptors from Thyme Alters Fear-Related Hippocampal Activity
Int. J. Mol. Sci., Aug 2023 | DOI: 10.3390/ijms241713148
🌿 Explores a thyme-derived compound affecting ASIC and GABA receptors linked to anxiety.

 

 

 

Yuniesky Andrade-Talavera | Neuroscience | Best Innovation Award

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🌟Dr. Yuniesky Andrade-Talavera, Neuroscience, Best Innovation Award🏆

Doctorate at Universidad Pablo de Olavide, Spain

Yuniesky Andrade Talavera is a Marie Skłodowska-Curie Postdoctoral Fellow at the Universidad Pablo de Olavide (UPO), Spain. His research expertise lies in neurophysiology, neuronal network dynamics, neuropharmacology, neurodegenerative disorders, and synaptic plasticity.

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Yuniesky Andrade Talavera has published 32 peer-reviewed articles, 23 of which appear in Q1 journals according to the Journal Citation Reports (JCR). He has an h-index of 17 and an i10-index of 21, with his work receiving a total of 842 citations on Google Scholar and 677 on Scopus.

Education

Andrade Talavera completed his Ph.D. at the Universidad Pablo de Olavide, Spain, in 2012, earning Cum Laude honors. He also holds a Master’s degree from both the Universidad Pablo de Olavide and the National Centre for Scientific Research in Cuba, obtained in 2009. His academic journey began with a Bachelor’s degree in Biology from the University of Havana, Cuba, in 2004.

Research Focus

His research focuses on understanding the mechanisms of synaptic plasticity, the dynamics of neuronal networks, and the pathology of neurodegenerative disorders like Alzheimer’s disease. He investigates the roles of neurons and glial cells in brain rhythmicity and synaptic behavior, aiming to uncover therapeutic strategies for cognitive impairments.

Professional Journey

Andrade Talavera has held various research positions, starting as a Ph.D. student at UPO, followed by postdoctoral roles at UPO and the Karolinska Institutet in Sweden. His work at these institutions involved significant contributions to understanding long-term synaptic depression and neuronal network oscillations in neurodegenerative conditions.

Honors & Awards

He has received multiple honors, including the Extraordinary Ph.D. Award from UPO in 2013, a Postdoctoral College Grant from the Wenner-Gren Foundation in 2019, and the Seal of Excellence from the European Commission in 2022. Additionally, he was awarded a Marie Curie Postdoctoral Fellowship and a research grant from the Regional Andalusia Government’s Excellence Program.

Publications Noted & Contributions

Significant publications include articles in Trends in Neuroscience and Molecular Psychiatry, highlighting his work on synaptic plasticity and neuronal oscillations. Notable contributions include discovering mechanisms of long-term synaptic depression and identifying therapeutic targets for Alzheimer’s disease.

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer’s disease

Journal: Progress in Neurobiology
Publication Date: April 2024
DOI: 10.1016/j.pneurobio.2024.102585
ISSN: 0301-0082
Contributors: Riccardo Maccioni, Caterina Travisan, Jack Badman, Stefania Zerial, Annika Wagener, Yuniesky Andrade-Talavera, Federico Picciau, Caterina Grassi, Gefei Chen, Laetitia Lemoine, et al.
Summary: This study investigates the role of Signal peptide peptidase-like 2b (SPPL2b) in Alzheimer’s disease (AD). The research demonstrates that SPPL2b modulates the amyloidogenic pathway and its expression is dependent on amyloid-beta (Aβ) presence. The findings suggest that targeting SPPL2b could provide new therapeutic avenues for managing AD.

Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

Journal: Translational Neurodegeneration
Publication Date: 2023
DOI: 10.1186/S40035-023-00338-0
WOSUID: WOS:000924688700001
Contributors: Luis Enrique Arroyo-Garcia, Sara Bachiller, Rocio Ruiz, Antonio Boza-Serrano, Antonio Rodriguez-Moreno, Tomas Deierborg, Yuniesky Andrade-Talavera, André Fisahn
Summary: This research explores the potential of targeting galectin-3 to mitigate the disruption of spike-phase coupling in fast-spiking interneurons, which is crucial for gamma oscillations in the brain. The study’s outcomes indicate that galectin-3 modulation could restore gamma oscillations and ameliorate cognitive deficits in Alzheimer’s disease.

Timing to be precise? An overview of spike timing-dependent plasticity, brain rhythmicity, and glial cells interplay within neuronal circuits

Journal: Molecular Psychiatry
Publication Date: June 2023
DOI: 10.1038/s41380-023-02027-w
Contributors: Yuniesky Andrade-Talavera, André Fisahn, Antonio Rodríguez-Moreno
Summary: This comprehensive review addresses the intricate mechanisms of spike timing-dependent plasticity (STDP), brain rhythmicity, and the role of glial cells in neuronal circuits. It highlights the significance of precise timing in neuronal communication and plasticity, with implications for understanding and treating neurological disorders.

Neuronal and astrocyte determinants of critical periods of plasticity

Journal: Trends in Neurosciences
Publication Date: May 2023
DOI: 10.1016/j.tins.2023.04.005
ISSN: 0166-2236
Contributors: Yuniesky Andrade-Talavera, Mikel Pérez-Rodríguez, José Prius-Mengual, Antonio Rodriguez-Moreno
Summary: This article examines the roles of neurons and astrocytes in determining the critical periods of synaptic plasticity. The authors discuss how these cell types influence plasticity windows, which are essential for cognitive development and neuroplasticity, providing insights into potential therapeutic strategies for neurodevelopmental and neurodegenerative diseases.

Differential neural circuit vulnerability to β-amyloid and tau pathologies in novel Alzheimer’s disease mice

Publication Date: April 12, 2023
DOI: 10.1101/2023.04.12.536603
Contributors: Maria Dolores Capilla-López, Angel Deprada, Yuniesky Andrade-Talavera, Irene Martínez-Gallego, Heriberto Coatl-Cuaya, José Rodríguez-Alvarez, Antonio Rodríguez-Moreno, Arnaldo Parra-Damas, Carlos A. Saura
Summary: This preprint presents research on the differential vulnerability of neural circuits to β-amyloid and tau pathologies using a novel Alzheimer’s disease mouse model. The study provides detailed insights into how specific neural circuits are affected differently by these pathological proteins, contributing to the understanding of disease progression and potential targets for intervention.

Research Timeline

From 2006 to 2022, Andrade Talavera progressed from a researcher candidate in Cuba to a Marie Curie Postdoctoral Fellow in Spain. Key periods include his postdoctoral research at the Karolinska Institutet (2016-2020) and his ongoing fellowship at UPO since 2023.

Collaborations and Projects

He has collaborated on 21 research projects, leading eight as principal investigator. His projects have secured funding from various Swedish bodies and the Regional Andalusia Government. Collaborative efforts have resulted in significant findings related to neuronal network dynamics and Alzheimer’s disease, often in partnership with international researchers.

Research Projects

Yuniesky Andrade Talavera has led several projects focused on Alzheimer’s disease, investigating therapeutic interventions and the role of neuronal networks. Key projects include funding from the Foundation for Geriatrics Diseases and the Swedish Research Council, emphasizing translational research to counteract amyloid-beta-induced cognitive deficits.