Shemiakin-Ovchinnikov Institute of bioorganic chemistry RAS, Russia.
Dr. Sergey Kozlov is a DSc and Head of the Laboratory of Neuroreceptors and Neuroregulators at the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry. He also teaches at the Federal State Russian Biotechnological University. His research focuses on the rational search for active molecules and the analysis of their structure-function relationships, particularly for potential healthcare applications. His most notable contributions include discovering ligands for acid-sensitive ion channels, which have promising therapeutic potential for treating pain, inflammation, drug addiction, anxiety, and neurodegenerative conditions such as stroke.
Profile
🎓 Education
Prof. Sergey Kozlov is a distinguished scientist and educator specializing in bioorganic chemistry and biotechnology. He earned his Doctor of Science (DSc) from the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry, where he conducted advanced research in biochemical processes and molecular interactions. Currently, he serves as a teaching faculty member at the Federal State Russian Biotechnological University, where he contributes to academic development and scientific research in biotechnology. With extensive expertise in biomolecular studies, Prof. Kozlov plays a crucial role in training future researchers and advancing innovation in bioorganic chemistry.
💼 Experience
Professor Sergey Kozlov is the Head of the Laboratory of Neuroreceptors and Neuroregulators at the Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry. He is also a Professor & Researcher at the Federal State Russian Biotechnological University. Additionally, he collaborates with various Russian chemical laboratories on the functional testing of low molecular weight compounds.
His expertise likely involves bioorganic chemistry, neurobiology, and possibly pharmacology, with a focus on receptor interactions and the regulation of neurochemical processes in the brain.
🔬 Research Interests
Dr. Kozlov's research focuses on protein chemistry, including:
Separation of natural mixtures and structure determination
Activity analysis of compounds using imaging and electrophysiology
Development of animal models for testing new molecules
Production of recombinant proteins and receptor mutagenesis
His work has contributed significantly to understanding acid-sensitive ion channels, which play a role in pain management, inflammation, addiction, anxiety, and neurodegeneration.
🏆 Awards & Recognitions
Member – The International Society on Toxinology
Member – Federation of European Biochemical Societies (FEBS)
Hirsch Index: 28 (WoS)
Patents: 19 published, 2 under review
Consultancy/Industry Projects: 2 completed
Research Projects: 6 (4 completed, 2 ongoing)
📚 Selected Publications
Mutagenesis of the Peptide Inhibitor of ASIC3 Channel Introduces Binding to Thumb Domain of ASIC1a but Reduces Analgesic Activity
Marine Drugs, Aug 2024 | DOI: 10.3390/md22090382
🧬 Examines peptide inhibitors of ASIC3 channels and their effect on pain relief.
Opioid Analgesic as a Positive Allosteric Modulator of Acid-Sensing Ion Channels
Int. J. Mol. Sci., Jan 2024 | DOI: 10.3390/ijms25031413
💊 Investigates opioid analgesics as modulators of ASIC channels for potential pain management.
Venom-gland transcriptomics and proteomics of the Tibellus oblongus spider
Dataset, Oct 2023 | DOI: 10.6084/m9.figshare.21842034
🕷️ Provides genomic insights into spider venom composition.
Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
Int. J. Mol. Sci., Sep 2023 | DOI: 10.3390/ijms241813884
🏛️ Reviews five decades of toxin research at IBCh RAS.
Dual Modulator of ASIC Channels and GABA<sub>A</sub> Receptors from Thyme Alters Fear-Related Hippocampal Activity
Int. J. Mol. Sci., Aug 2023 | DOI: 10.3390/ijms241713148
🌿 Explores a thyme-derived compound affecting ASIC and GABA receptors linked to anxiety.