Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award

Dr. Dasiel Oscar Borroto Escuela | Neuroscience | Research Excellence Award 

University of Malaga | Spain

Dr. Dasiel Oscar Borroto Escuela is an internationally recognized neuroscientist whose research has fundamentally advanced the understanding of G protein–coupled receptor (GPCR) heteroreceptor complexes and their role in brain function and disease. His work focuses on elucidating how alterations in GPCR heteroreceptor complexes and their allosteric receptor–receptor interactions contribute to the pathogenesis of neuropsychiatric and neurodegenerative disorders, including major depression, addiction, and Parkinson’s disease. Dr. Borroto Escuela is a pioneer in the discovery and characterization of GPCR–GPCR and GPCR–RTK interactions in the central nervous system, providing compelling molecular evidence that these complexes constitute critical integrative signaling units underlying learning, memory, and brain plasticity. His seminal publications in Biological Psychiatry, Molecular Psychiatry, Neuropsychopharmacology, and Trends in Pharmacological Sciences have reshaped prevailing neurotransmitter hypotheses by introducing receptor heterocomplex dynamics as key determinants of disease vulnerability and therapeutic response. A major contribution of his work is the proposal that changes in the density and allosteric interactions of GPCR heterocomplexes represent a shared molecular mechanism linking psychiatric and neurodegenerative disorders. He has notably extended the serotonin hypothesis of depression by integrating molecular dynamics within serotonin receptor heterocomplexes, identifying new targets for antidepressant intervention. Dr. Borroto Escuela has also developed and refined cutting-edge methodologies, including the establishment and optimization of in situ proximity ligation assay (PLA) techniques, enabling the in-brain visualization of GPCR heteroreceptor complexes—a methodological breakthrough that has become foundational in the field. His characterization of heteromer interface interactions, such as the D2R–A2AR heterodimer, has opened new avenues for drug development using small interfering peptides. Currently, as an EMERGIA Fellow at the University of Málaga, Dr. Borroto Escuela leads the Receptomics & Brain Disease Lab, while simultaneously directing the GPCR Laboratory at Karolinska Institutet. He has secured competitive funding from prestigious Spanish and Swedish agencies and foundations and has produced over 180 peer-reviewed publications, with more than 5,000 citations and an h-index exceeding 40. Beyond research, he is deeply committed to scientific leadership, serving as editor and editorial board member for leading journals, evaluator for international funding agencies, supervisor of over 60 students, and an invited speaker at more than 40 international conferences. His career reflects sustained excellence, innovation, and global impact in neuroscience and neuropsychopharmacology.

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Featured Publications

Prof. Jolanta Dorszewska | Neurobiology | Best Researcher Award

Prof. Jolanta Dorszewska | Neurobiology | Best Researcher Award

Poznan University of Medical Sciences, Poland.

Professor Jolanta Dorszewska is a distinguished neuroscientist and full professor at the Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poland. With over three decades of research and academic leadership, she has made pioneering contributions to the understanding of neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. As the head of her department since 2004, she continues to inspire innovation in molecular neurobiology, epigenetics, and neurochemistry.

Profile

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🎓 Education

Prof. Dorszewska’s academic journey began at the Faculty of Pharmacy, Poznan University of Medical Sciences, where she earned her MSc in Pharmacy (1987) with distinction. She continued her academic growth with a PhD (1996) in medical sciences and attained postdoctoral habilitation (2004). She became a Full Professor in 2016, after rigorous training and board certifications in pharmaceutical analytics and medical genetics.

💼 Professional Experience

Her professional path is deeply rooted in neuroscience and pharmacology. She served as an assistant in the Departments of Pharmacy and Clinical Neurochemistry before becoming a Research Associate and later the Head of the Laboratory of Neurobiology. Internationally, she gained experience as a Research Scientist in New York (1999-2000). She has also taught extensively, including at the National High Medical School in Piła.

🔬 Research Interests

Prof. Dorszewska’s research covers a rich spectrum—from analyzing lipid and sterol levels in hypoxia to the genetic and molecular pathways of neurodegeneration. Her work involves advanced techniques like HPLC, ELISA, Western Blot, PCR, and focuses on biomarkers, genetic polymorphisms, miRNAs, and apoptosis in diseases such as Alzheimer’s, Parkinson’s, epilepsy, and migraine. She is especially known for studies on homocysteine metabolism and catecholamine gene mutations.

🏆 Awards & Recognition

She has earned numerous accolades and holds editorial and leadership roles in prestigious journals including Frontiers in Molecular Neuroscience, Journal of Integrative Neuroscience, and Current Alzheimer Research. As a Guest Editor for six major neuroscience journals and a member of international neurological associations, her global contributions to science are widely respected. She was also an Honorary Member of the 12th CONy World Congress (2018).

📚 Selected Publications

🧬 Genetics and Parkinson's Disease

Title: Genetic variants of ZNF746 and the level of plasma Parkin, PINK1, and ZNF746 proteins in patients with Parkinson's disease
Journal: IBRO Neuroscience Reports
Date: June 2025
DOI: 10.1016/j.ibneur.2025.01.016
Authors: Jolanta Dorszewska et al.
🔬 Focus: Investigates the role of ZNF746 gene variants and related proteins in the pathophysiology of Parkinson’s disease.

🧠 Neurorehabilitation and Multiple Sclerosis

Title: Kinesiotherapeutic Possibilities and Molecular Parameters in Multiple Sclerosis
Journal: Sclerosis
Date: April 3, 2025
DOI: 10.3390/sclerosis3020013
Authors: Katarzyna Wiszniewska et al., including Jolanta Dorszewska
🧘‍♀️ Focus: Explores physical therapy interventions and their molecular impacts in MS patients.

🦠 Parasitic Infections and Proteinopathies

Title: Unraveling the Role of Proteinopathies in Parasitic Infections
Journal: Biomedicines
Date: March 3, 2025
DOI: 10.3390/biomedicines13030610
Authors: Mikołaj Hurła et al., including Jolanta Dorszewska
🧫 Focus: Connects neurodegenerative proteinopathies with parasitic infection mechanisms.

🧪 Neuropharmacology and Aging

Title: Expression of Neuronal Nicotinic Acetylcholine Receptor and Early Oxidative DNA Damage in Aging Rat Brain—The Effects of Memantine
Journal: International Journal of Molecular Sciences
Date: February 14, 2025
DOI: 10.3390/ijms26041634
Authors: Małgorzata Anna Lewandowska et al., including Jolanta Dorszewska
🧠 Focus: Studies the impact of Memantine on aging-related neurochemical changes.

🧠 Brain Imaging and Migraine

Title: fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura
Journal: Neurology International
Date: January 21, 2025
DOI: 10.3390/neurolint17020015
Authors: Damian Pikor et al., including Jolanta Dorszewska
🧲 Focus: Uses fMRI to explore visual cortex abnormalities in migraine with aura.