Jiayi Zheng | Vaccine Development | Research Excellence Award

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Ms. Jiayi Zheng | Vaccine Development | Research Excellence Award

Master’s student in Shantou University Medical College, China

Ms. Jiayi Zheng is a Master’s student in Immunology at Shantou University Medical College, focusing on virus-vectored multivalent enterovirus vaccine research with part of her work published in an SCI-indexed journal. She previously completed a Bachelor’s degree in Medical Laboratory Technology from Shaoguan University, earning three consecutive National Endeavor Scholarships. She also gained practical clinical experience through a ten-month internship at Yuebei People’s Hospital. Her technical expertise includes cell culture, Western blotting, immunofluorescence, flow cytometry, ELISA, and laboratory mouse handling. She received a bronze award at the First National Graduate Academic Innovation and Achievement Transformation Competition. Her research applied immunoinformatics to identify key epitopes from EV71, CA16, and CA6 viruses. These epitopes were fused with an attenuated CVB3 vector to construct a novel vaccine candidate, rCV-A3V. Intranasal immunization in BALB/c mice successfully induced strong mucosal, humoral, and Th1-biased cellular immune responses. Notably, sIgA antibodies targeting multiple enteroviruses were detected in the milk of lactating mice, indicating potential maternal–neonatal passive immunity. This work highlights an innovative strategy for multivalent enterovirus vaccine development and supports the feasibility of intranasal immunization approaches.

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Featured Publications

 

Tewin Tencomnao | Immunology | Best Researcher Award

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Assist. Prof. Dr. Tewin Tencomnao | Immunology | Best Researcher Award

Dean at Chulalongkorn University, Thailand

Assist. Prof. Dr. Tewin Tencomnao is the Head of the Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing at Chulalongkorn University, where he also serves as Assistant Professor in Clinical Chemistry and Dean of the Faculty of Allied Health Sciences. He holds a Ph.D. in Biochemistry and Molecular Biophysics from Virginia Commonwealth University and a B.Sc. in Medical Technology (Honors) from Chulalongkorn University. His research spans drug discovery, natural products, molecular biology, biochemistry, neuroscience, anti-ageing, and mechanisms of neuropsychiatric diseases. Dr. Tencomnao has authored more than 205 publications, accumulating over 10,636 citations, and maintains a strong h-index of 34, reflecting his influence in neuroprotection and natural product research. He has received several prestigious recognitions, including the 2021 Fulbright Thai Visiting Scholar Award (University of Kentucky), the 2020 Outstanding Researcher Award of Chulalongkorn University, the 2015 DMSc Award from the Ministry of Public Health for his groundbreaking work on Rhinacanthus nasutus, and a 2015 international Gold Award for innovation for developing an anti-ageing cream derived from natural resveratrol. He has contributed extensively to scientific literature through numerous book chapters covering medicinal Thai herbs, neuroprotection, phytochemistry, natural anti-ageing compounds, probiotics, and medicinal plant responses to environmental stresses, with recent works published by CRC Press, Taylor & Francis, Elsevier, Springer Nature, and Bentham Science. His scholarly outputs highlight significant advances in natural neuroprotectants, autophagy regulation, medicinal plant proteomics, anti-glutamate neurotoxicity mechanisms, and therapeutic potentials of phytochemicals in ageing and neurodegeneration, establishing him as a leading authority in natural product-based biomedical innovation.

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Featured Publications

Areekul, P., Bhunyakarnjanarat, T., Suebnuson, S., Somsri, K., Trakultritrung, S., Taveethavornsawat, K., Tencomnao, T., Boonyasuppayakorn, S., & Leelahavanichkul, A. (2025). Less severe inflammation in cyclic GMP–AMP synthase (cGAS)-deficient mice with rabies: Impact of mitochondrial injury and gut–brain axis. Biology, 14(11), 1583. https://doi.org/10.3390/biology14111583

Alugoju, P., Palanisamy, C. P., Anthikapalli, N. V. A., Jayaraman, S., Prasanskulab, A., Chuchawankul, S., Dyavaiah, M., & Tencomnao, T. (2024). Exploring the anti-aging potential of natural products and plant extracts in budding yeast Saccharomyces cerevisiae: A review. F1000Research, 13, 141669. https://doi.org/10.12688/f1000research.141669.2

Alugoju, P., Bhandare, V. V., Patil, V. S., Krishna Swamy, V. K. D., Borugadda, P. K., & Tencomnao, T. (2024). In silico molecular docking and molecular dynamic simulation of agarwood compounds with molecular targets of Alzheimer’s disease. F1000Research, 13, 130618. https://doi.org/10.12688/f1000research.130618.2

Janpaijit, S., Sukprasansap, M., Tencomnao, T., & Prasansuklab, A. (2024). Anti-neuroinflammatory potential of areca nut extract and its bioactive compounds in anthracene-induced BV-2 microglial cell activation. Nutrients, 16(17), 2882. https://doi.org/10.3390/nu16172882

Pattarachotanant, N., Sukjamnong, S., Rangsinth, P., Chaikhong, K., Sillapachaiyaporn, C., Leung, G. P.-H., Hu, V. W., Sarachana, T., Chuchawankul, S., Tencomnao, T., et al. (2024). Aquilaria crassna extract exerts neuroprotective effect against benzo[a]pyrene-induced toxicity in human SH-SY5Y cells: An RNA-seq-based transcriptome analysis. Nutrients, 16(16), 2727. https://doi.org/10.3390/nu16162727

Sharika, R., Mongkolpobsin, K., Rangsinth, P., Prasanth, M. I., Nilkhet, S., Pradniwat, P., Tencomnao, T., & Chuchawankul, S. (2024). Experimental models in unraveling the biological mechanisms of mushroom-derived bioactives against aging- and lifestyle-related diseases: A review. Nutrients, 16(16), 2682. https://doi.org/10.3390/nu16162682

Tedasen, A., Chiabchalard, A., Tencomnao, T., Yamasaki, K., Majima, H. J., Phongphithakchai, A., & Chatatikun, M. (2024). Anti-melanogenic activity of ethanolic extract from Garcinia atroviridis fruits using in vitro experiments, network pharmacology, molecular docking, and molecular dynamics simulation. Antioxidants, 13(6), 713. https://doi.org/10.3390/antiox13060713