Quotient Sciences, United States
Profile
orcid
🎓 Early Academic Pursuits
Kyle A. Frey began his scientific journey with a rigorous academic foundation that included two years of medical school training at Thomas Jefferson Medical College. This early exposure to the intricacies of clinical medicine uniquely positioned him with an interdisciplinary understanding of pharmaceutical sciences, bridging the gap between patient care and drug development. His academic experiences fueled his desire to pivot toward formulation science, where he could more directly impact drug performance and patient outcomes.
🧪 Professional Endeavors
Currently serving as Formulation Scientist III at Quotient Sciences in Wilmington, DE, Kyle has amassed over 12 years of cumulative experience in pharmaceutical sciences. He leads end-to-end drug development projects, starting from initial drug substance characterization and preformulation assessment to formulation design, scale-up, and GMP manufacturing for clinical trials. Known for his independent thinking and technical versatility, Kyle excels in resolving complex formulation challenges and optimizing products for scalability and commercialization.
📚 Contributions and Research Focus
Kyle’s research has consistently pushed the boundaries of pharmaceutical innovation. His focus on novel drug delivery systems, solid and liquid oral formulations, and low-dose mixing technologies has earned him international recognition. His groundbreaking work in resonant acoustic mixing (RAM) was showcased at AAPS PharmSci 360 in 2023, positioning him at the forefront of low-dose blending technologies. His hands-on use and thought leadership in ASAPprime™ accelerated stability testing further highlight his contributions to long-term formulation stability and predictive modeling.
🌍 Impact and Influence
A recognized thought leader, Kyle was provisionally selected for the “Best Researcher Award” in the International Top Pharmaceutical Awards and listed in Marquis Who’s Who 2024 as one of America’s Distinguished Scientists. These honors reflect not only the depth of his technical expertise but also his influence within the global pharmaceutical community. His work directly supports translational pharmaceutics-based clinical trials, impacting real-world therapeutic delivery.
🔬 Academic Citations and Publications
Kyle’s innovative research is documented in top-tier journals, with recent publications in Pharmaceutical Research (2023) and the International Journal of Pharmaceutics (2025). He is also registered with ORCID (0000-0003-1361-4960) and holds a Web of Science Researcher ID (LXA-8444-2024), ensuring his contributions are accessible and citable by academics and professionals alike.
🧰 Technical Skills and Expertise
Kyle is proficient in a wide array of analytical and formulation equipment and techniques. His expertise spans thermal (DSC, MDSC, TGA), chromatographic and spectroscopic (HPLC, UPLC, GC, FTIR), and physical testing (SEM, Karl Fischer, laser diffraction, density measurements). Additionally, his deep understanding of solid and liquid formulation equipment, including Korsch automated presses, spray dryers, and functional coaters, makes him a go-to SME for development and scale-up.
👨🏫 Teaching and Mentorship
An enthusiastic mentor and patient teacher, Kyle is dedicated to cultivating the next generation of scientists. He regularly mentors junior scientists, providing training on both laboratory techniques and critical thinking skills. His strong communication abilities and engaging presentation style have also made him a well-received speaker and educator, both within his organization and at scientific conferences.
🧭 Legacy and Future Contributions
Kyle’s journey is far from over. With a strong drive for innovation and a proven record of solving complex formulation problems, he continues to envision a future where drug development is smarter, faster, and more patient-centered. His lifelong commitment to learning, along with his desire to make impactful contributions to science and society, positions him as a rising luminary in pharmaceutical formulation and manufacturing.
📚 Publication
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Title: Sample Preparation Techniques to Enhance Uniformity of Low-Dose Blends Mixed by Resonant Acoustic Mixing Technology
Authors: Frey, K.A., Baker, H., Purcell, D.K., Lewis, A.L.
Journal: International Journal of Pharmaceutics
Year: 2025
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Title: Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process (Poster Presentation)
Authors: Frey, K.A., Baker, H., Purcell, D.K., Lewis, A.L., Engers, D.A.
Journal/Conference: AAPS PharmSci 360
Year: 2023
Poster ID: M1230-11-79
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Title: Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process
Authors: Frey, K.A., Baker, H., Purcell, D.K., Lewis, A.L., Engers, D.A.
Journal: Pharmaceutical Research
Year: 2023
Citations: Web of Science (4), CrossRef (5), Google Scholar (7)
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Title: Sample Preparation Techniques to Enhance Uniformity of Low-Dose Blends Mixed by Resonant Acoustic Mixing Technology (Pre-print)
Authors: Frey, K.A., Baker, H., Purcell, D.K., Lewis, A.L.
Platform: SSRN Pre-Print, International Journal of Pharmaceutics
Year: 2025