Dr. Minzhao Lin | DNA nanomachines, smart hydrogels, ultrasound-responsive systems, tumor diagnostics | Best Researcher Award
Dezhou University, China
Profile
Early Academic Pursuits
Dr. Minzhao Lin embarked on his academic journey with a robust foundation in Biology and Medicine, earning his Ph.D. from the prestigious Sun Yat-sen University. His early interest in nanomedicine and molecular systems set the stage for a research trajectory deeply rooted in interdisciplinary innovation. During his doctoral years, he delved into biosensors and DNA nanotechnology, gaining the technical acumen and experimental rigor that would later define his contributions to biomedical engineering and diagnostics.
Professional Endeavors
Currently serving as a Lecturer at Dezhou University’s Institute of Rural Revitalization, Dr. Lin leads a dynamic research group focused on fusing DNA nanotechnology with smart drug delivery and biosensing platforms. His position allows him to mentor young scientists while pushing forward impactful projects that address real-world healthcare and environmental challenges. Despite a primarily academic focus, Dr. Lin maintains strong collaborative ties with institutions like the University of Pittsburgh and Sun Yat-sen University, reflecting his global academic presence.
Contributions and Research Focus
Dr. Lin's research revolves around DNA nanomachines, smart hydrogels, and ultrasound-responsive platforms, with applications in tumor diagnostics and pathogen detection. A hallmark of his work is the development of a sustainable, regenerating DNA motor system that combines magnetic separation for multi-use diagnostics. This innovation drastically reduces assay costs while enabling ultrasensitive detection of viral RNA and pesticide residues—achieving detection at the femtomolar level. His ability to integrate nanotechnology into applicable diagnostic systems places him at the forefront of translational biomedical innovation.
Impact and Influence
With over 525 citations and an h-index of 13 on Google Scholar, Dr. Lin’s publications have reached an international audience and inspired parallel research in biosensor development and molecular diagnostics. His work has been featured in high-impact journals and is frequently cited by researchers working on next-generation biosensors, indicating both academic excellence and societal relevance. His research is also particularly timely given global concerns about infectious diseases, food safety, and environmental toxins.
Academic Citations & Publications
Dr. Lin has authored numerous SCI and Scopus-indexed journal articles, establishing a strong academic footprint in the field of nanobiotechnology. Though he has not published any books, his scientific articles and patents (8 total, with 5 published and 3 under review) showcase a prolific output of peer-reviewed and innovation-based work. His ORCID profile 0000-0001-9697-3656 offers comprehensive access to his academic contributions.
Technical Skills
Dr. Lin is proficient in a suite of modern molecular tools, including DNA origami, hydrogel synthesis, nanomaterial fabrication, molecular diagnostics, and magnetic nanoparticle systems. His interdisciplinary training enables him to lead projects from conceptual design to prototype validation. This skill set is crucial in developing multifunctional biosensors for field and clinical use.
Teaching Experience
As a lecturer, Dr. Lin not only conducts high-impact research but also actively mentors undergraduate and postgraduate students in biomedical and molecular engineering. He integrates research insights into his teaching, cultivating a new generation of researchers equipped to tackle complex problems in diagnostics and therapeutics.
Legacy and Future Contributions
Dr. Minzhao Lin’s innovative spirit is reflected in his vision to make smart, sustainable diagnostics accessible across healthcare and environmental sectors. His pioneering DNA motor technology represents a shift toward affordable, reusable biosensors, which could dramatically improve diagnostic access in rural and underdeveloped regions. Looking forward, Dr. Lin aims to expand his research into clinical applications of nanomaterials and AI-integrated biosensing platforms, positioning himself as a long-term contributor to global health innovation.
Selected Publications
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**Lin M**, Rui Wang, et al.
Magnetic Multipedal DNA Walking Nanomachine Driven by Catalytic Hairpin Assembly
Analytical Chemistry, 2023.
Describes a magnetic DNA‑walking nanomachine enabling enhanced signal amplification and easy magnetic separation for rapid miRNA analysis site.convention.co.jp+4pubs.acs.org+4researchgate.net+4researchgate.net. -
**Lin M**, Rui Wang, et al.
Self‑Feedback DNAzyme Motor for Cascade‑Amplified Imaging of mRNA in Live Cells and In Vivo
(Journal), 2024 (approx.).
Focuses on multi‑component DNA nanomachines with catalytic activity for fluorescent imaging of mRNA in live cell and in vivo contexts researchgate.net. -
Chengyu Yan, Yulin Hua, Jiarong Guo, Peng Miao, Lin M, Rui Wang, et al.
Programmable DNA Hydrogels Construction with Functional Regulations for Biosensing Applications
Trends in Analytical Chemistry, Feb 2024.
Introduces programmable DNA hydrogels regulated for biosensing purposes, showcasing innovative DNA‑based responsive materials researchgate.net+1pmc.ncbi.nlm.nih.gov+1. -
(Haohao Chen, Min Yuan, Fengqin Yin, Fei Xu; Lin M listed co-author on related research)
Freezing‑Driven Assembly of DNA Walking Machine Facilitates G₄ Nanowires Growth for Electrochemical Detection of Kanamycin
(Journal), Mar 2025.
Demonstrates a DNA walking system creating G₄ nanowires for electrochemical pesticide detection