Anna Klimovich | Biochemistry | Young Scientist Award

Published on by Invention Awards

Dr. Anna Klimovich | Biochemistry | Young Scientist Award 

Dr. Anna Klimovich | G.B. Elyakov Pacific Institute of Bioorganic Chemistry Far-Eastern Branch of the Russian Academy of Sciences | Russia

Dr. Anna Klimovich is a PhD candidate in biochemistry with a decade of experience as a research fellow, specializing in the investigation of biologically active compounds derived from marine organisms of the Far Eastern and tropical seas using advanced experimental models of human pathologies in laboratory animals. She works as a research assistant in the Laboratory of Molecular Pharmacology and Biomedicine at the Pacific Institute of Bioorganic Chemistry, contributing extensively to fundamental and applied biomedicine. Her scientific portfolio includes 40 publications indexed in Web of Science and Scopus, supported by 199 citations across 162 documents and an h-index of 8, reflecting her strong research impact. She has completed seven research projects and is an inventor or co-inventor on seven patents focused on bioactive marine compounds and their therapeutic potential. Her research areas span biology, biochemistry, biomedicine, natural biologically active substances, and preclinical trials, with collaborative work involving Far Eastern Federal University in Vladivostok. Dr. Klimovich has contributed significantly to the characterization of marine peptides and metabolites, including the sea anemone peptide HCRG21, which exhibits analgesic, anti-inflammatory, and anxiolytic activities and demonstrates therapeutic potential for allergic dermatitis and psoriasis. She has also studied the peptide HCIQ2c1 with anti-inflammatory and neuroprotective properties, and the sea anemone peptides Hcr 1b-2, Hcr 1b-4, and AnmTX Sco 9a-1, which show strong anxiolytic, anti-inflammatory, and analgesic effects. Her work further includes discovering the antidiabetic and antiglycemic activities of the peptide Mgf, evaluating antimicrobial and antitumor effects of phenylphascaplysine alkaloid derivatives, and identifying the ability of triterpene glycosides from sea cucumbers—Cucumarioside A0-1, Djakonovioside A—and the peptide Hct-S3 to inhibit tumor metastasis. Additionally, she contributed to demonstrating that asterripeptides A–C from marine fungi possess therapeutic activity in treating infected wounds. Her research advances marine-derived therapeutic discoveries with high relevance to pharmacology, biotechnology, and translational biomedicine.

Profiles: Scopus | Orcid

Featured Publications

Klimovich, A., Kvetkina, A., Deryavko, Y., Priymenko, N., Popkova, D., Bystritskaya, E., Isaeva, M., Gladkikh, I., Sintsova, O., & Leychenko, E. (2025). TRPV1 blocker, peptide HCRG21 from sea anemone Heteractis magnifica, exhibits effectiveness in psoriasis and dermatitis in in vivo models. International Journal of Molecular Sciences, 26(21), 10644. https://doi.org/10.3390/ijms262110644

Klimovich, A. A., Chingizova, E. A., Pislyagin, E. A., Kotelnikov, V. N., & Shperling, I. A. (2025). Eksperimental’no-funktsional’naya otsenka ranozazhivlyayushchey aktivnosti gidrogelya na osnove karboksimetiltsellyulozy s biologicheski aktivnymi veshchestvami iz gidrobiontov Tikhogo okeana pri termicheskom ozhoge [Experimental and functional evaluation of the wound-healing activity of a carboxymethylcellulose-based hydrogel with bioactive substances from Pacific Ocean hydrobionts in a thermal burn model]. Clinical and Fundamental Medicine, 2, 5–12. https://doi.org/10.24866/3033-5485/2025-2/5-12

Zhidkov, M. E., Smirnova, P. A., Grammatikova, N. E., Isakova, E. B., Shchekotikhin, A. E., Styshova, O. N., Klimovich, A. A., & Popov, A. M. (2025). Comparative evaluation of the antibacterial and antitumor activities of marine alkaloid 3,10-dibromofascaplysin. Marine Drugs, 23(2), 68. https://doi.org/10.3390/md23020068

Klimovich, A. A., Kvetkina, A. N., Deryavko, Y. V., Priymenko, N. A., & Leychenko, E. V. (2024). Peptide TRPV1 channel blocker, HCRG21, effectively suppresses inflammation in a calcipotriol-induced allergic dermatitis model. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18, (Issue no. pending). https://doi.org/10.1134/S1990750824601127

Pavlenko, A. P., Klimovich, A. A., Yurchenko, E. A., Kvetkina, A. N., & Leychenko, E. V. (2024). Sea anemone Heteractis magnifica toxin Hct-S3 suppresses the migration of solid Ehrlich adenocarcinoma cells inoculated into BALB/C mice. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry, 18, (Issue no. pending). https://doi.org/10.1134/S1990750824601206

Klimovich, A. A., Styshova, O. N., Popov, A. M., Moskvina, T. V., Tsybulsky, A. V., Derunov, D. A., & Stonik, V. A. (2020). Experimental study of therapeutic efficacy of the topical preparation “Kourochitin” in skin allergy. Letters in Drug Design & Discovery, 17(10), 1234–1241.

Aralov Andrey | Nucleic Acids Biochemistry | Best Researcher Award 

Published on by Invention Awards

Prof. Aralov Andrey | Nucleic Acids Biochemistry | Best Researcher Award 

Prof. Aralov Andrey | IBCH RAS | Russia

Prof. Aralov Andrey holds a PhD (2011) in the chemical synthesis of natural and modified oligonucleotides using the phosphotriester method and currently serves as the Head of the Group of Molecular Tools for Living System Studies at the Institute of Bioorganic Chemistry, Russian Academy of Sciences (since 2018). Since 2013, he has curated and executed multiple competitive grants funded by the Russian Scientific Foundation for Basic Research and the Russian Science Foundation, contributing extensively to innovations in nucleic acid chemistry, molecular tools, aptamers, pH-responsive sensors, antiviral nucleosides, red-light fluorescent systems, and genomic DNA i-motif technologies. He is the author of more than seventy publications indexed in Scopus and Web of Science, with a strong track record in high-impact journals including Nucleic Acids Research, Sensors and Actuators B: Chemical, Current Issues in Molecular Biology, ACS Sensors, Nature Communications, Biosensors and Bioelectronics, and others. His notable works span DNA aptamer architectures with high affinity for influenza A virus, diversification of i-motif-based pH sensors, advances in nucleoside antiviral mechanisms, Mango-based red-light RNA tracking systems, ratiometric i-motif long-term pH monitoring tools, mechanistic studies of oxidized DNA lesions, and cell-free prototyping strategies for therapeutic peptides and proteins. His research outputs have been cited 548 times across 396 documents, reflecting his significant impact in the fields of nucleic acid chemistry and molecular biosensing, with an h-index of 14. In addition to his research achievements, he has authored several postgraduate-level courses on nucleic acid chemistry, contributing to advanced scientific training in the field.

Profiles: Scopus | Orcid | Staff Page

Featured Publications

Boldinova, E. O., Kruchinin, A. A., Kamzeeva, P. N., Aralov, A. V., & Makarova, A. V. (2025). Accurate DNA synthesis across 8-oxoadenine by human PrimPol. International Journal of Molecular Sciences, 26(14), 6796.

Kamzeeva, P. N., Alferova, V. A., Korshun, V. A., Varizhuk, A. M., & Aralov, A. V. (2025). 5′-UTR G-quadruplex-mediated translation regulation in eukaryotes: Current understanding and methodological challenges. International Journal of Molecular Sciences, 26(3), 1187.

Kruchinin, A. A., Kamzeeva, P. N., Zharkov, D. O., Aralov, A. V., & Makarova, A. V. (2024). 8-Oxoadenine: A “new” player of the oxidative stress in mammals? International Journal of Molecular Sciences, 25(2), 1342.

Kamzeeva, P., Dagaev, N., Lizunova, S., Khodarovich, Y., Sogomonyan, A., Kolchanova, A., Pokrovsky, V., Alferova, V., Chistov, A., Eshtukov-Shcheglov, A., et al. (2023). Synthesis and biological evaluation of benzo[4,5]- and naphtho[2′,1′:4,5]imidazo[1,2-c]pyrimidinone derivatives. Biomolecules, 13(11), 1669.

Knizhnik, E., Chumakov, S., Svetlova, J., Pavlova, I., Khodarovich, Y., Brylev, V., Severov, V., Alieva, R., Kozlovskaya, L., Andreev, D., et al. (2023). Unwinding the SARS-CoV-2 ribosomal frameshifting pseudoknot with LNA and G-clamp-modified phosphorothioate oligonucleotides inhibits viral replication. Biomolecules, 13(11), 1660.

Kamzeeva, P., Petushkov, I., Knizhnik, E., Snoeck, R., Khodarovich, Y., Ryabukhina, E., Alferova, V., Eshtukov-Shcheglov, A., Belyaev, E., Svetlova, J., et al. (2023). Phenotypic test of benzo[4,5]imidazo[1,2-c]pyrimidinone-based nucleoside and non-nucleoside derivatives against DNA and RNA viruses, including coronaviruses. International Journal of Molecular Sciences, 24(19), 14540.

Kamzeeva, P. N., Aralov, A. V., Alferova, V. A., & Korshun, V. A. (2023). Recent advances in molecular mechanisms of nucleoside antivirals. Current Issues in Molecular Biology, 45(8), 433.

 

Miguel Angel Alcantara-Ortigoza | Human Molecular Genetics | Best Researcher Award

Published on by Invention Awards

Dr. Miguel Angel Alcantara-Ortigoza | Human Molecular Genetics | Best Researcher Award

Academic Researcher in National Institute of Pediatrics, Mexico

Dr. Miguel Angel Alcantara-Ortigoza is a medical scientist with doctoral training in Molecular Biology, specializing in monogenic diseases and congenital malformations. His work at INP contributed to advancing the molecular understanding of inherited disorders, and he currently serves as Director of the Molecular Diagnosis Area at the DNA-GEN SC laboratory, where he has nearly 20 years of experience implementing and supervising molecular diagnostic testing for approximately 15,000 patients across Mexico and Latin America. He collaborates with rehabilitation centers, hospitals, private laboratories, and pharmaceutical companies such as Sanofi-Genzyme and Roche in areas including newborn screening and orphan drug development. With 72 publications, more than 554 citations across 523 documents, and an h-index of 14, he has established a strong scientific footprint in human genetics. His collaborations particularly with Prof. Marcela Vela Amieva’s group have led to pivotal contributions describing the genotypic spectrum underlying inborn metabolic diseases in Mexico. His research group reported the first molecular prenatal diagnosis for a monogenic disease in Mexico and recently proposed a rational diagnostic approach for families affected by orofacial clefts to enhance genetic counseling. His work continues to impact clinical genetics, molecular diagnostics, and the genomic characterization of congenital and metabolic disorders.

Profiles: Scopus | Orcid | Google Scholar | Staff Page

Featured Publications

Alcántara-Ortigoza, M. A., Vela-Amieva, M., González-del Angel, A., Reyna-Fabián, M. E., Fernández-Hernández, L., Estandía-Ortega, B., Guillén-López, S., López-Mejía, L., Ibarra-González, I., & Ruiz-Reyes, M. de la L. (2025). Biparental and androgenetic somatic mosaicism with presentation of non-syndromic severe neonatal hyperinsulinemia. International Journal of Molecular Sciences, 26(16), 7985.

Fernández-Lainez, C., Vela-Amieva, M., Reyna-Fabián, M., Fernández-Hernández, L., Guillén-López, S., López-Mejía, L., Alcántara-Ortigoza, M. Á., González-del Angel, A., Carrillo-Nieto, R. I., & Ortega-Valdez, E. (2024). Isolated methylmalonic acidemia in Mexico: Genotypic spectrum, report of two novel MMUT variants and a possible synergistic heterozygosity effect. Molecular Genetics and Metabolism Reports, 41, 101155.

Vela-Amieva, M., Alcántara-Ortigoza, M. A., González-del Angel, A., Fernández-Hernández, L., Reyna-Fabián, M. E., Estandía-Ortega, B., Guillén-López, S., López-Mejía, L., Belmont-Martínez, L., & Carrillo-Nieto, R. I. (2024). Concordance between biochemical and molecular diagnosis obtained by WES in Mexican patients with inborn errors of intermediary metabolism: Utility for therapeutic management. International Journal of Molecular Sciences, 25(21), 11722.

Alcántara-Ortigoza, M. A., Rodríguez-Lozano, A. L., Estandía-Ortega, B., González-del Angel, A., Díaz-García, L., Rivas-Larrauri, F. E., & Nájera-Velázquez, R. G. (2024). Does the esv3587290 copy number variation in the VANGL1 gene differ as a genetic factor for developing nephritis in Mexican childhood-onset systemic lupus erythematosus patients? Children, 11(6), 712.

Vela-Amieva, M., Alcántara-Ortigoza, M. A., González-del Angel, A., Ibarra-González, I., Fernández-Hernández, L., Guillén-López, S., López-Mejía, L., & Fernández-Lainez, C. (2023). In silico structural protein evaluation of the phenylalanine hydroxylase p.(Tyr77His) variant associated with benign hyperphenylalaninemia as identified through Mexican newborn screening. Children, 10(12), 1865.

González-del Angel, A., Ruiz-Herrera, A., Hernández-Martínez, N. L., Todd-Quiñones, C. G., Durán-McKinster, C., Herrera-Mora, P., & Alcántara-Ortigoza, M. A. (2023). Uncommon large and bilateral fibrous cephalic plaques in a patient with TSC2-related tuberous sclerosis complex. Children, 10(10), 1614.

González-del Angel, A., Alcántara-Ortigoza, M. A., Ramos, S., Algara-Ramírez, C., Hernández-Hernández, M. A., & Saenger-Rivas, L. (2023). Unusual trisomy X phenotype associated with a concurrent heterozygous 16p11.2 deletion: Importance of an integral approach for proper diagnosis. International Journal of Molecular Sciences, 24(19), 14643.

Ashton, C. J., Perveen, R., Beaman, G., Crisponi, G., González-del Angel, A., Garza-Mayén, G., Alcántara-Ortigoza, M. A., O’Sullivan, J., & Clayton-Smith, J. (2022). 3MC syndrome: Molecular findings in previously reported and milder patients expand the natural history and phenotypic spectrum. Clinical Dysmorphology, 31(4), 157–165.